Table of Contents
- 1 What is the relationship between particle size and deposition rate?
- 2 What factors influence deposition?
- 3 What is the average deposition rate?
- 4 How is deposition rate calculated?
- 5 What size particle can make it into the alveoli?
- 6 What is deposition speed?
- 7 How does particle size affect regional lung deposition?
- 8 How does inspiratory flow rate affect particle deposition?
What is the relationship between particle size and deposition rate?
First, particle size is seen to be an important factor influencing deposition rates. For example, the central tendency of the experimental data shows an increase in deposition rate from T 0.1 h-1 for 0.2 μm particles to T 1 h-1 for 2.5 μm particles.
What factors influence deposition?
With respect to the anatomy of the respiratory tract, important parameters are the diameters, the lengths, and the branching angles of airway segments, which determine the deposition. Physiological factors include airflow and breathing patterns, which influence particle deposition.
How particle size affects deposition and distribution of drugs in the airway?
The larger the particle size, the greater the velocity of incoming air, the greater the bend angle of bifurcations and the smaller the airway radius, the greater the probability of deposition by impaction .
What do the particles do in deposition?
The opposite of sublimation is deposition. This is the process in which a gas changes directly to a solid without going through the liquid state. It occurs when gas particles become very cold.
What is the average deposition rate?
Sediment deposition rates decrease across the floodplain with distance from the channel bank, and the average rate of deposition is 1.4 cm/a over the first 1 km.
How is deposition rate calculated?
Calculate the area of the circle -> Radius squared * pi. Multiply times the density of the metal being used. Multiply times the wire feed speed. Multiply times 60 (to get deposition rate per hour if wire feed speed was expressed per minute)
What are the 4 types of deposition?
Types of depositional environments
- Alluvial – type of Fluvial deposit.
- Aeolian – Processes due to wind activity.
- Fluvial – processes due to moving water, mainly streams.
- Lacustrine – processes due to moving water, mainly lakes.
What are the 4 factors that influence the rate of deposition?
In the physics of aerosols, the forces acting on a particle and its physical and chemical properties, such as particle size or size distribution, density, shape, hygroscopic or hydrophobic character, and chemical reactions of the particle will affect the deposition.
What size particle can make it into the alveoli?
When the air gets to the alveolar region (the lower lung area), it has slowed even more. The air is essentially calm. Particulates that make it this far into the lungs are usually 0.5 µm or smaller. They enter the lung essentially by randomly landing on the membrane or other parts of the lung.
What is deposition speed?
The rate of deposition, or the deposition velocity, is slowest for particles of an intermediate size. Mechanisms for deposition are most effective for either very small or very large particles. Deposition velocity is defined from F = vc, where F is flux density, v is deposition velocity and c is concentration.
What are 3 examples of deposition?
Examples of Gas to Solid (Deposition)
- Water vapor to ice – Water vapor transforms directly into ice without becoming a liquid, a process that often occurs on windows during the winter months.
- Physical vapor to film – Thin layers of material known as “film” are deposited onto a surface using a vaporized form of the film.
Which of the following is the best example of deposition?
The most typical example of deposition would be frost. Frost is the deposition of water vapour from humid air or air containing water vapour on to a solid surface. Solid frost is formed when a surface, for example a leaf, is at a temperature lower than the freezing point of water and the surrounding air is humid.
How does particle size affect regional lung deposition?
Sedimentation is a time-dependent process in which particles settle due to the influence of gravity. Hence, breathing maneuvers in which more time is allowed for the particles to sediment (e.g. breath-holding) may increase lung deposition ( Zeng et al., 2001 ).
How does inspiratory flow rate affect particle deposition?
Ultimately, inspiratory flow rate also plays an important role in the particle deposition following pulmonary administration ( Dolovich, 2000 ).
How does the Stokes law affect lung deposition?
Hence, breathing maneuvers in which more time is allowed for the particles to sediment (e.g. breath-holding) may increase lung deposition ( Zeng et al., 2001 ). The Stokes’ Law assumes that the relative velocity between the surface of the particle and the airstream is null.
Where are large particles most likely to impact?
Therefore, considering the bifurcated architecture of the lungs, large particles travelling through the airways at high airflow velocity are more likely to impact in the proximal portion of the respiratory tract (upper airways) ( Zeng et al., 2001 ). 2.2. Sedimentation